This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (144)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

PRELIMINARY REPORT

Manucher Javid, M.D.; Paul Settlage, M.D., Ph.D.

J Am Med Assoc. 1956;160(11):943-949.

Abstract
• Urea in amounts as high as 1 gm. per kilogram of body weight can be injected intravenously in the form of sterile, fresh 30% solution in 5% dextrose. Urea was used without causing toxic reactions in 21 patients. The desired reduction in cerebrospinal fluid pressure was accomplished in every case. There was no secondary rise such as is seen after injections of hypertonic solutions of sodium chloride and dextrose, and the blood pressure was unaffected.

Heat must not be used to sterilize the urea solution. If the technique is carefully followed, it should be valuable in brain surgery for the reduction of intracranial pressure.

Author Affiliations
Madison, Wis.

From the departments of neurosurgery and anatomy, University of Wisconsin Medical School.

Footnotes
Prof. Frank L. Kozelka made the urea nitrogen determinations.

This work was supported in part by funds from the University of Wisconsin Medical School Research Committee.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hyponatremia in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone: Rapid Correction With Urea, Sodium Chloride, and Water Restriction Therapy
Decaux et al.
JAMA 1982;247:471-474.
ABSTRACT  

Urea Therapy for Inappropriate Antidiuretic Hormone Secretion From Tuberculous Meningitis
Decaux et al.
JAMA 1980;244:589-590.
ABSTRACT  

Clinical Review : Acute Bacterial Meningitis in Childhood: An Outline of Management
Murray et al.
CLIN PEDIATR 1972;11:455-464.
ABSTRACT  

The Effect of Hypertonic Urea on Cerebral Edema in the Rabbit Induced by Triethyl Tin Sulfate
LEVY et al.
Arch Neurol 1965;13:58-64.
ABSTRACT  

Intravenous Hypertonic Urea in the Management of Acute Angle-Closure Glaucoma
HILL et al.
Arch Ophthalmol 1961;65:497-503.
ABSTRACT  

The Clinical Use of Urea for Reduction of Intraocular Pressure
DAVIS et al.
Arch Ophthalmol 1961;65:526-531.
ABSTRACT