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TRACHOMA-STUDIES OF ETIOLOGY, LABORATORY DIAGNOSIS, AND PREVENTION
J. Thomas Grayston, M.D.;
San-Pin Wang, M.D.;
Robert L. Woolridge, M.S.;
Yen-Fei Yang, M.D.;
Paul B. Johnston, Ph.D.
JAMA. 1960;172(15):1577-1586.
Abstract
Material from 116 human eyes infected with trachoma was used successfully for the isolation of viruses by culturing in the yolk sac of chick embryos. Five strains of virus were isolated. All five killed embryos on second passage, and all five fixed complement with both serum from patients with lymphogranuloma venereum and a guinea pig psittacosis antiserum. The virus thus made available for laboratory study was used in tests for sensitivity to drugs. Penicillin, sulfisoxazole, and oxytetracycline were effective against the virus even in the smallest amounts used. The virus produced typical acute follicular conjunctivitis in six human volunteers. A vaccine was produced from the virus and elicited a significant antibody response in monkeys and human subjects. Evidence that the vaccine had both preventive and curative value was obtained.
Author Affiliations
Taipei, Taiwan (Formosa)
From the United States Naval Medical Research Unit no. 2 (NAMRU-2), the Department of Ophthalmology, National Taiwan University College of Medicine, and the Department of Medicine, University of Chicago.
Footnotes
Read before the 52nd annual meeting of the Formosan Medical Association, Taipei, Nov. 21, 1959.
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