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Computer Analysis of 520 Cases

Edmund L. Dubois, MD; Denny L. Tuffanelli, MD

JAMA. 1964;190(2):104-111.

Abstract
Diagnosis of systemic lupus erythematosus (SLE) was confirmed by the presence of lupus erythematosus cells in 75.7% of the patients, findings of skin biopsies in 6.0% and of renal biopsies in 1.2%, and by the clinical picture alone in 17.1%. Negroes comprised 34% of the subjects. Spontaneous remissions occurred in 35% of the patients. Proven familial SLE occurred in 2%. Myalgia was present in 48.2%. No history of cutaneous involvement at any time was found in 28%. Classic skin lesions of chronic discoid lupus at the onset of their illness were present in 10.8%. Urinary abnormalities were noted in only 46.1%. Uremia caused 34% of the 135 deaths and progressive central nervous system involvement caused 18.4%. The prognosis has markedly improved. The mean duration is now 94.8 months for the entire series versus 38.5 months in an untreated control group.

Author Affiliations
Los Angeles

From the departments of medicine and dermatology of the University of Southern California School of Medicine and from the Los Angeles County General Hospital.

Footnotes
Reprint requests to 2025 Zonal Ave, Los Angeles 33 (Dr. Dubois).

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