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Dengue Fever: A Thrombocytopenic Disease?
Ethel R. Nelson, MD;
Howard R. Bierman, MD
JAMA. 1964;190(2):99-103.
Abstract
In a study of dengue fever in Thailand, bone-marrow examinations showed hypocellularity early in the disease, followed by hypercullarity during recovery and normocellularity in convalescence. Thrombocytopenia due to megakaryocytic suppression was a characteristic. In 18 patients with early dengue, thrombocytopenia lasted one to four days; platelet counts in 8 were less than 50,000/cu cm. Petechiae or other bleeding manifestations were noted in 15 patients. Intensive hematologic studies of dengue infections in other geographic areas are suggested, to determine if thrombocytopenia is a universal characteristic of this and related virus diseases.
Author Affiliations
Bangkok, Thailand; Beverly Hills, Calif
From Bangkok Sanitarium and Hospital (Dr. Nelson) and the Institute for Cancer and Blood Research (Dr. Bierman).
Footnotes
Reprint requests to 321 S Robertson Blvd, Beverly Hills, Calif (Dr. Bierman).
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