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Robert J. Sperber, MD; Leonard B. Di Re, MD; Mark M. Singer, MD; Solomon Fisch, MD, PhD; Arthur C. DeGraff, MD

JAMA. 1965;191(9):703-706.

Abstract
Ethacrynic acid was effective in completely reversing pathological fluid retention in 13 of the 14 patients studied. The long-term studies in 29 patients demonstrated the effectiveness and relative safety of the drug when used in cases of true diuretic need over a period of months. The dose had to be individualized, but was generally 50 mg twice daily in digitalized patients. When used in higher doses or in combination with other effective diuretics, the marked fluid loss occasionally resulted in serious changes in electrolyte balance. Therefore, caution is necessary when introducing this new and useful oral diuretic in instances in which it is truly needed for effective management of pathological fluid retention.

Author Affiliations
From the Cardiac Therapy Research Unit, Medical Service, VA Hospital (Drs. Sperber, Di Re, Singer, and Fisch), and New York University School of Medicine (Dr. DeGraff), New York.

Footnotes
Reprint requests to 130 W Kingsbridge Rd, New York 10468 (Dr. Sperber).

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