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Henry G. Bryan, MD; Robert K. Nixon, MD

JAMA. 1965;192(3):203-208.

Abstract
Four or possibly five males in a kinship group had features of dyskeratosis congenita, a syndrome comprising poikiloderma atrophicans vasculare, dystrophia unguium, and leukoplakia oris. In addition, three members of the kinship demonstrated hematologic changes compatible with the hypoplastic anemia described by Fanconi. Based on the hemopoietic disturbance found in these three cases and that observed in seven similar cases from the literature, it is believed that the abnormalities associated with dyskeratosis congenita should be considered a further variant of the diverse congenital defects encompassed by the syndrome of Fanconi's familial pancytopenia.

Author Affiliations
From the Department of Dermatology and the Fifth Medical Division, Henry Ford Hospital, Detroit.

Footnotes
Read before the Section on Dermatology during the 113th annual convention of the American Medical Association, San Francisco, June 23, 1964.

Reprint requests to 2799 W Grand Blvd, Detroit 48202 (Dr. Nixon).

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