 |
|
Heparin Osteoporosis
George C. Griffith, MD;
George Nichols, Jr., MD;
John D. Asher, MD;
Barry Flanagan, MD
JAMA. 1965;193(2):91-94.
Abstract
Studies of 117 patients on long-term sodium heparin therapy disclosed cumulative evidence of a relationship between prolonged use of large amounts of heparin and osteoporosis. No symptoms of osteoporosis developed in 107 who received 10,000 units of concentrated sodium heparin once daily or less for 1 to 15 years. Of ten treated daily with larger doses (15,000 to 30,000 units) for six months or longer, spontaneous fractures of vertebrae or ribs developed in six, and biopsies disclosed soft, bony matrix. Studies of rats on sufficient heparin therapy to triple clotting for ten days indicated that collagenolytic activity of rat-bone-cell homogenate increased two to four times, and the stability of the lysosome-like bodies in bone cells which contain collagenase appears to be decreased. If these observations are true, hyperheparin states, whether spontaneous or man-induced, may take their place in the small growing category of lysosomal diseases.
Author Affiliations
From the Department of Medicine, University of Southern California School of Medicine and Los Angeles County Hospital, Los Angeles, and the Department of Medicine, Harvard Medical School, and the Peter Bent Brigham Hospital, Boston.
Footnotes
Read in part before the annual meeting of the American Society for Clinical Investigation, Atlantic City, NJ, May 2, 1965.
Reprint requests to 1136 W 6th St—Suite 111, Los Angeles 90017 (Dr. Griffith).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Managing heparin anticoagulation in patients with prosthetic cardiac valves: balancing the risk
Shlebak and Malik
Heart 2009;95:1643-1645.
FULL TEXT
Risk of Posttransfusion Hepatitis in the United States: A Prospective Cooperative Study
JAMA 1972;220:692-701.
ABSTRACT
Anticoagulants in Treatment of Patients With Hip Fracture
Wessler and Avioli
JAMA 1968;204:140-144.
ABSTRACT
|
