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-Globulin in the Prophylaxis of Posttransfusion Hepatitis

Paul V. Holland, MD; Richard M. Rubinson, MD; Andrew G. Morrow, MD; Paul J. Schmidt, MD

JAMA. 1966;196(6):471-474.

Abstract
Commercial -globulin given shortly before open-heart surgery and then one month later was ineffective in reducing the incidence of posttransfusion icteric hepatitis. There were 11 cases in 84 treated patients, 6 in 83 control patients. Half of the cases of hepatitis had an incubation period of less than 50 days and neither this nor the severity of disease was affected by the -globulin treatment.

Author Affiliations
From the Clinical Center Blood Bank and the National Heart Institute, National Institutes of Health, Bethesda, Md. Dr. Rubinson is now at the Yale-New Haven Medical Center, New Haven, Conn.

Footnotes
Read in part before the annual meeting of the American Association of Blood Banks, Miami, Fla, September 1965.

Reprint requests to Blood Bank Department, Clinical Center, National Institutes of Health, Bethesda, Md 20014 (Dr. Holland).

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