This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Some Hazards of Long-Term Drug Therapy

Alvin S. Zelickson, MD

JAMA. 1966;198(4):341-344.

Abstract
In the past two years there have been several reports dealing with the unusual discoloration present in the sunexposed sites of patients receiving prolonged and high doses of chlorpromazine. The general consensus has been that it is due to a melanin or a melanin-plus-drug combination. Electron-microscopic examination of both normal and involved skin from these patients, as well as examination of extracts and residues of normal and involved skin of these patients following the extraction of chlorpromazine from the tissue, strongly suggests that the peculiar blue-gray color presented by these patients is due to a combination of both the drug and melanin rather than to melanin by itself.

Author Affiliations
From the Division of Dermatology, University of Minnesota Medical School, Minneapolis.

Footnotes
Reprint requests to Division of Dermatology, University of Minnesota Hospitals, 412 Union St SE, Minneapolis 55455.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Guide to the Problem of Photosensitivity
Kalivas
JAMA 1969;209:1706-1709.
ABSTRACT