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Association With Hyperglycinuria, Dominantly Inherited Microphthalmia, and Cataracts

Crawford W. Adams, MD; Walter E. Nance, MD

JAMA. 1967;202(6):525-530.

Abstract
A 35-year-old woman underwent diagnostic studies because of an 18-year history of paroxysmal tachycardia, hypertension, syncope, and seizures. The studies and postmortem examination failed to reveal any recognized cause for the cardiac symptoms. Associated findings included dominantly inherited microphthalmia with cataracts, and hyperglycinuria with renal stones. The findings appear to constitute an unusual genetically determined syndrome resulting from a still uncharacterized abnormality in glycine metabolism.

Author Affiliations
From the Department of Medicine, Vanderbilt University Medical School, Nashville, Tenn.

Footnotes
Adapted from a chairman's address read before a joint meeting of the Section on Diseases of the Chest with the Section on Preventive Medicine and the American College of Chest Physicians, at the 116th annual convention of the American Medical Association, Atlantic City, NJ, June 19, 1967.

Reprint requests to 21st and Hayes Medical Building, Nashville, Tenn 37203 (Dr. Adams).

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