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LTC James W. Bass, MC; CPT Saul H. Cohen, MC; MAJ Joseph D. Corless, MC; CPT Peter Mamunes, MC

JAMA. 1967;202(8):697-702.

Abstract
A clinical study was performed to compare the effectiveness of three currently employed antimicrobial regimens to each other and to that of ampicillin in the treatment of acute otitis media in children. Four hundred children with acute otitis media were treated by randomization with one of four therapeutic regimens: (1) oxytetracycline, (2) a single injection of procaine penicillin G and penicillin G benzathine plus orally administered sulfisoxazole, (3) phenoxymethyl penicillin potassium plus sufisoxazole, or (4) ampicillin for seven days. The relative effectiveness of each therapeutic regimen was judged in a double-blind manner. The therapeutic responses in the four different treatment groups were not significantly different; however, relapses were more common after oxytetracycline.

Author Affiliations
USA; USA; USA; USA

From the Pediatric Service, Madigan General Hospital, Tacoma, Wash. Dr. Bass is now with Tulane University School of Medicine, New Orleans.

Footnotes
This material has been reviewed by the Office of the Surgeon General, Department of the Army, and there is no objection to its presentation and/or publication. This review does not imply any endorsement of the opinions advanced or any recommendations of such products as may be named.

Read in part before the Symposium on Broad-Spectrum Pencillins, sponsored by the New York Academy of Sciences, New York, Dec 13, 1966.

Reprint requests to 1430 Tulane Ave, New Orleans 70112 (Dr. Bass).

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