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II. Double-Blind Study Designed to Assess the Prophylactic Efficacy of an Analogue of Amantadine Hydrochloride

Albert T. Dawkins, Jr., MD; Lawrence R. Gallager, MD; Richard B. Hornick, MD; Barton A. Harris, MD

JAMA. 1968;203(13):1095-1099.

Abstract
A single double-blind study conducted with 55 volunteers showed clearly that Exp 126 (alpha-methyl-1-adamantanemethylamine hydrochloride, rimantadine hydrochloride), an analogue of amantadine hydrochloride, reduced the occurrence and severity of artificially induced Asian influenza in humans. The infection (or seroconversion) rate in the drug-dosed and placebo-dosed groups was almost 100%, although the increase in serum neutralizing antibody levels was significantly less in the Exp 126-dosed subjects. The infecting influenza virus was recovered only from placebo-dosed controls. Probable untoward reactions from the drug occurred in three volunteers. Two related drugs, amantadine hydrochloride and rimantadine hydrochloride are now available for the prevention of Asian influenza.

Author Affiliations
From the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore.

Footnotes
Reprint requests to 29 S Greene St, Baltimore 21201 (Dr. Togo).

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