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Leonard S. Kaplow, MD; John A. Goffinet, MD

JAMA. 1968;203(13):1135-1137.

Abstract
Patients undergoing hemodialysis manifest marked temporary neutropenia occurring 2 to 15 minutes after the start of dialysis, followed by an increase in band neutrophils. Total leukocyte counts return to near normal levels approximately one hour later. The phenomenon is not due to simple filtration of leukocytes by the dialyzer nor to heparin sodium administration, and is independent of the administration set or the infusion pump mechanism. Rebound leukocytosis is not observed, and the neutropenia is unaccompanied by chills, fever, or other symptoms usually associated with intravenous infusions of pyrogenic substances.

Author Affiliations
From the Veterans Administration Hospital, West Haven, Conn, and the departments of pathology (Dr. Kaplow) and medicine (Dr. Goffinet), Yale University School of Medicine, New Haven, Conn.

Footnotes
Reprint requests to Veterans Administration Hospital, W Spring Street, West Haven, Conn 06516 (Dr. Kaplow).

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