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Association With Diazepam Therapy

Hewitt F. Ryan, MD; F. Bruce Merrill, MD; George E. Scott, MD; Richard Krebs, MD; Betty L. Thompson, RN

JAMA. 1968;203(13):1137-1139.

Abstract
Seven cases occurred in which there was an association in time between the institution of diazepam therapy and the onset of suicidal thoughts and tendencies, which tended to be concealed by patients who were at the time receiving psychiatric treatment. An additional patient demonstrated deepening of depression while receiving diazepam. Physicians should consider the possible adverse depressive effect of diazepam when prescribing it as an antianxiety agent.

Author Affiliations
From Denver General Hospital (Drs. Ryan, Scott, and Krebs, and Mrs. Thompson), Mount Airy Hospital (Drs. Ryan and Merrill), and Bethesda Hospital (Dr. Ryan), Denver.

Footnotes
Reprint requests to Denver General Hospital, W Sixth Ave and Cherokee St, Denver 80204 (Dr. Ryan).

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