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James D. Beard, PhD; David H. Knott, MD, PhD

JAMA. 1968;204(2):135-139.

Abstract
Total body water, extracellular volume, and plasma volume were measured in 30 well-nourished, chronic alcoholics. Plasma and erythrocyte electrolyte concentration and excretion were measured. Isosmotic overhydration with normal concentrations was found on admission to the hospital. With no specific fluid or electrolyte therapy, total body water level decreased to normal four days later. Abnormal liver function was found in all patients. Empirical and ubiquitous use of fluids in alcoholics, presumed to be dehydrated, may only exacerbate overhydration.

Author Affiliations
From the Alcohol Research Center (Dr. Beard), and the Alcoholic Rehabilitation Unit (Dr. Knott), Tennessee Psychiatric Hospital and Institute, and the University of Tennessee Medical Units, Memphis (Drs. Beard and Knott).

Footnotes
Reprint requests to 865 Poplar Ave, Memphis, Tenn 38105 (Dr. Beard).

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