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Dextroamphetamine-Sulfate-Induced Dyskinesias
Richard H. Mattson, MD;
John R. Calverley, MD
JAMA. 1968;204(5):400-402.
Abstract
Dyskinesia developed in four patients soon after the administration of therapeutic doses of dextroamphetamine sulfate. The movements were tic-like, dystonic, and similar to those occasionally produced by phenothiazines, and they promptly disappeared when the use of the drug ceased. They probably represented idiosyncratic reactions rather than extension of the pharmacologic effects of amphetamines. It is possible that the dextroamphetamine unmasked a subclinical extrapyramidal disorder in these patients.
Author Affiliations
From the Division of Neurology, the University of Texas Medical Branch, Galveston, Tex. Dr. Mattson is now with Yale University, New Haven, Conn.
Footnotes
Reprint requests to the University of Texas Medical Branch, Galveston, Tex 77550 (Dr. Calverley).
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