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Leukocyte Granulation and Leukocyte Alkaline Phosphatase

Fred Rosner, MD; Gerald Weisfogel; Arthur Feinerman

JAMA. 1968;205(12):873-875.

Abstract
Leukocyte granulation and alkaline phosphatase activity in leukocytes were studied in a group of patients with infantile amaurotic familial idiocy (Tay-Sachs disease) and a comparable group of control children. Statistically significant differences could not be demonstrated. The only patient in this series with late infantile amaurotic familial idiocy (Bielschowsky-Jansky disease) showed increased granulation of the neutrophils in his peripheral blood as well as an elevated alkaline phosphatase value in the leukocytes.

Author Affiliations
From the Division of Hematology, Department of Medicine, Maimonides Medical Center, Brooklyn, NY (Dr. Rosner); and the State University of New York, Downstate Medical Center, Brooklyn (Messrs. Weisfogel and Feinerman).

Footnotes
Reprint requests to 4802 Tenth Ave, Brooklyn, NY 11219 (Dr. Rosner).

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