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Anaphylaxis to Cephalothin in a Patient Allergic to Penicillin
Joseph F. Scholand, MD;
James I. Tennenbaum, MD;
G. James Cerilli, MD
JAMA. 1968;206(1):130-132.
Abstract
In a patient allergic to penicillin, a severe anaphylactic reaction developed on first exposure to cephalothin. There is evidence to suggest that the cross-reactivity of cephalothin and penicillin occurs through the penicilloyl determinant. Therefore, patients who are sensitive to penicillin and who exhibit positive penicilloyl-polylysine skin tests have a greater risk of reaction to cephalothin therapy.
Author Affiliations
From the departments of medicine and surgery of the Ohio State University Medical Center, Columbus.
Footnotes
Reprint requests to University Hospital, Columbus, Ohio 43210 (Dr. Tennenbaum).
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