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Comparative Study in Man

Jon I. Isenberg, MD; A. Marvin Brooks, MD; Morton I. Grossman, MD, PhD

JAMA. 1968;206(13):2897-2898.

Abstract
In 20 male patients with various gastrointestinal disorders, gastric acid secretion was studied, once following administration of pentagastrin, 6µg/kg of body weight, and once following administration of betazole hydrochloride, 1.5 mg/kg, each injected subcutaneously. The peak responses to the two stimulants were not significantly different and were strongly correlated. The peak response to pentagastrin was more rapid in onset and less sustained than the response to betazole. Pentapeptide produced fewer side effects.

Author Affiliations
From the Veterans Administration Center and the departments of medicine and physiology, University of California School of Medicine, Los Angeles.

Footnotes
Reprint requests to Veterans Administration Center, Bldg 115, Room 115, Los Angeles 90073 (Dr. Grossman).

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