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An Alternative to Quinine

LT Steven J. Berman, MC

JAMA. 1969;207(1):128-130.

Abstract
Successful therapy for falciparum malaria is of current interest because of the American commitment in South Vietnam and the chloroquine-resistant strains encountered there. With quinine-pyrimethamine-diaminodiphenylsulfone therapy, radical cures can be expected in more than 95% of the patients. An alternative regimen employs chloroquine, pyrimethamine, and sulfisoxazole and excludes quinine. Seventy-six patients treated with this combination at Naval Support Activity Hospital, DaNang, Republic of Vietnam, were rapidly and radically cured. Furthermore, the duration of fever was shorter when chloroquine was used in combination in the place of quinine.

Author Affiliations
USNR

From the US Naval Medical Research Unit No. 2, Taipei, Taiwan, and the US Naval Support Activity Hospital, DaNang, Vietnam.

Footnotes
The opinions and assertions contained herein are those of the author and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

Reprint requests to Publications Office, NAMRU-2, Box 14, APO San Francisco 96263.

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