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Lembitu Reio, PhD; Lennart Wetterberg, MD

JAMA. 1969;207(1):148-150.

Abstract
A false-positive reaction for urinary porphobilinogen (PBG) was observed in the untreated eluates obtained when the Mauzerall-Granick method was applied to urine samples of mental-hospital patients who were receiving phenothiazines. The interference may be derived from the phenothiazine medication given to the patients, either directly, or as one of the several possible metabolites, or from some singular dye constituent in the tablets. Two different chromatographic systems were designed to separate the possible interfering compound from PBG.

Author Affiliations
From the Department of Metabolic Research, the Wennergren Institute, University of Stockholm, and the Psychiatric Research Centre, University of Uppsala, Sweden. Dr. Wetterberg is now with the Department of Psychiatry, University of California, Los Angeles.

Footnotes
Reprint requests to Veterans Administration Center, Wilshire and Sawtelle boulevards, Los Angeles 90073 (Dr. Wetterberg).

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