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Immunologic Considerations

Thomas W. Self, MD; Teodoro Herskovic, MD; Emily Czapek, MD; Daniel Caplan, MD; Trudy Schonberger; Joyce D. Gryboski, MD

JAMA. 1969;207(13):2393-2396.

Abstract
Stool specimens were examined for precipitating antibodies to milk, soy, and cereal products from 25 children with chronic diarrhea without determined organic cause. Specimens were also obtained from 30 age-matched controls who had no gastrointestinal, respiratory, or allergic symptoms. Results of roentgenographic gastrointestinal examination and absorption studies revealed no abnormalities in 90% of the patients. Malabsorption pattern was present roentgenologically in three patients. Precipitating substances to milk, barley, wheat, rye, oats, fraction 3 of gluten, and soy were present singly or in combination in all of the study patients. All patients responded to elimination of the offending antigen by return to normal bowel habits, weight gain, and elevation of hemoglobin and serum albumin values.

Author Affiliations
From the departments of pediatrics and internal medicine, Yale University School of Medicine, New Haven, and the Yale-New Haven (Conn) Medical Center.

Footnotes
Reprint requests to 333 Cedar St, New Haven, Conn 06510 (Dr. Gryboski).

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