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Bilateral Parotid Gland Enlargement and Hyperlipoproteinemia
H. Benfer Kaltreider, MD;
Norman Talal, MD
JAMA. 1969;210(11):2067-2070.
Abstract
Sjögren's syndrome was the initial diagnosis of the physicians who referred five patients with bilateral, noninflammatory parotid gland enlargement. This diagnosis was not confirmed in any case. All five patients had elevated plasma triglyceride concentrations and mild diastolic hypertension. Increased intake of alcoholic beverages, abnormal glucose tolerance, and moderate obesity were frequently present. Massive replacement of the parotid gland tissue by fat was observed in two biopsy specimens. Restriction of calories, alcoholic beverages, and the percent of calories from carbohydrate resulted in regression of parotid gland size in three patients observed for more than three months. A modest short-term reduction in size of the parotid gland occurred in one other patient over a five-week period. Hypertriglyceridemia was also ameliorated by this dietary regimen.
Author Affiliations
From the Arthritis and Rheumatism Branch of the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md. Dr. Kaltreider is now with the University of California, San Francisco Medical Center.
Footnotes
Reprint requests to 9000 Rockville Pike, Bethesda, Md 20014 (Dr. Talal).
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