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Failure of Inactivated Influenza Vaccine to Protect an Aged Population
Donn J. D'Alessio, MD;
Paul M. Cox, Jr., MD;
Elliot C. Dick, PhD
JAMA. 1969;210(3):485-489.
Abstract
Asian influenza developed in 36 of 176 residents of a county home for the aged four weeks after 80% of the residents had received the second of two doses of influenza virus vaccine. In addition, 60% of the residents had been inoculated with two doses the previous fall. Disease incidence had no discernible relationship to vaccination, and failure to protect apparently resulted from low postinoculation antibody levels. Antigenicity of another vaccine was studied in 35 laboratory employes; 21 had no antibody response, and only 6 had fourfold or greater titer increases. Since apparent lack of potency was manifested by vaccines from three different manufacturers, these results suggest that inadequate potency of commercially obtained inactivated influenza virus vaccine may be a greater problem than is generally realized.
Author Affiliations
From the Respiratory Virus Research Laboratory, Department of Preventive Medicine, University of Wisconsin Medical School, Madison (Drs. D'Alessio and Dick), and the National Communicable Disease Center, Public Health Service, Atlanta (Dr. Cox). Dr. Cox is now with the Tropical Disease Section, Public Health Service, San Juan, PR.
Footnotes
Reprint requests to 437 Henry Mall, Madison, Wis 53706 (Dr. D'Alessio).
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