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A New Vaccine

Henry A. Cromwell, MD; Frank B. Brandon, PhD; I. William McLean, Jr., MD; Joseph F. Sadusk, Jr., MD

JAMA. 1969;210(8):1438-1442.

Abstract
The 437 residents (average age 78.3 years) and 203 employees (average age 40.0 years) of a retirement community were the subjects in a clinical study comparing immunological effectiveness and reactogenicity of two monovalent Hong Kong influenza vaccines—one a conventional, intact virus vaccine and the other a vaccine prepared from ethyl ether extracted influenza virus antigens. Vaccine pyrogenicity was virtually eliminated by ether treatment, and local and systemic subjective reactions in the antigen vaccinees were one-half to one-fourth as frequent as in the conventional vaccine group. The vaccines were of equal immunogenicity in both populations; however, resident serologic response greatly exceeded employee response presumably because of a youthful experience with a Hong Kong-like virus. Although the community members mingled freely with the general population during the Hong Kong epidemic, no influenzalike disease was observed.

Author Affiliations
From the Meadow Lakes Retirement Community, Hightstown, NJ (Dr. Cromwell); and the Medical and Scientific Affairs Division, Parke, Davis & Company, Detroit (Drs. Brandon, McLean, and Sadusk).

Footnotes
Reprint requests to PO Box 118 (GPO), Detroit 48232 (Dr. Brandon).

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