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Technetium Sulfide Tc 99m vs Gold Au 198

Robert E. Cantor, MD; Edwin M. Cohn, MD; Chung H. Park, MD; Bernard Shapiro, MD

JAMA. 1970;211(10):1677-1680.

Abstract
In 48 patients with suspected liver metastases, liver scans were performed with both technetium sulfide Tc 99m, and gold Au 198. In 90% of the patients, (43 of 48) the interpretations of the sulfur colloid and gold scans were similar. In 10%, (five of 48) the technetium sulfide Tc 99m scans were abnormal, while the corresponding gold Au 198 scans were normal. In all five cases, there was either histologic or strong clinical and laboratory evidence of liver disease. Thus, approximately 10% more intrahepatic lesions were demonstrated with technetium sulfide Tc 99m than with gold Au 198. Spleen scans were easily obtainable in 77% (37) of patients given technetium sulfide Tc 99m. In scanning for metastases, a nonpalpable liver had only a 23% chance (three of 13) of being abnormal, while a palpable liver had a 60% chance (18 of 30) of being abnormal.

Author Affiliations
From the departments of nuclear medicine, Division of Radiology (Drs. Cantor and Shapiro), and gastroenterology, Division of Medicine (Drs. Cohn and Park), Albert Einstein Medical Center, Northern Division, Philadelphia.

Footnotes
Reprint requests to Division of Radiology, Albert Einstein Medical Center, York and Tabor roads, Philadelphia 19141 (Dr. Cantor).

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