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William W. Miller, MD; Maria Delivoria-Papadopoulos, MD; Leonard Miller, MD; Frank A. Oski, MD

JAMA. 1970;211(11):1824-1826.

Abstract
Two subjects with hyperthyroidism had increased release of oxygen from blood and elevated concentrations of red blood cell 2, 3-diphosphoglycerate. This organic phosphate can be established as the primary regulator of oxygen release from hemoglobin in this and in other clinical conditions with imbalance of oxygen supply and demand.

Author Affiliations
From the departments of pediatrics (Drs. W. Miller and Oski), physiology, Graduate Division (Dr. Delivoria-Papadopoulos), and surgery (Dr. L. Miller), University of Pennsylvania School of Medicine; Children's Hospital of Philadelphia (Dr. W. Miller); and the Hospital of the University of Pennsylvania (Drs. Oski and L. Miller), Philadelphia. Dr. W. Miller is now with the Department of Pediatrics, University of Texas Southwestern Medical School, Dallas.

Footnotes
Reprint requests to 5323 Harry Hines Blvd, Dallas 75235 (Dr. W. W. Miller).

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