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Interference by Spironolactone

Aron O. Lurie, MD, PhD

JAMA. 1970;211(11):1851-1852.

Abstract
A misleading, gross elevation of plasma cortisol levels was found in patients treated with spironolactone when a popular fluorometric technique for cortisol assay was employed. It was demonstrated that spironolactone interferes with the assay because its fluorescence emission spectrum is identical to that of cortisol. The assay of urinary 17-ketosteroids and 17-ketogenic steroids appears to be unaffected by the presence of spironolactone and can be used for the investigation of adrenal disease in patients taking the drug.

Author Affiliations
From the Department of Clinical Biochemistry, Boston City Hospital, and the Department of Medicine, Tufts School of Medicine, Boston.

Footnotes
Reprint requests to 818 Harrison Ave, Boston 02118 (Dr. Lurie).

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