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Kenneth H. Burdick, MD; Boyd Poulsen, PhD; Virgil A. Place, MD

JAMA. 1970;211(3):462-466.

Abstract
A number of extemporaneous corticosteroid preparations have been suggested in the literature. Unfortunately, this compounding of the corticosteroid and base is sometimes done without regard to the ultimate activity and stability of the product. A representative prescription filled by six pharmacies was compared with commercially formulated material. None of the six prescriptions was generally acceptable from the standpoint of pharmaceutical compounding, and all were inactive when tested in vasoconstriction studies.

Author Affiliations
From the institutes of clinical medicine (Dr. Burdick) and pharmaceutical science (Dr. Poulsen), Syntex Research Center; and the ALZA Corp. (Dr. Place), Palo Alto, Calif.

Footnotes
Reprint requests to 3401 Hillview Ave, Palo Alto, Calif 94304 (Dr. Burdick).

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