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Lung Biopsy and Roentgenographic and Physiologic Studies Before and During Treatment

Douglas R. Gracey, MD; Matthew B. Divertie, MD

JAMA. 1970;211(3):495-497.

Abstract
Lung biopsy during the course of intensive steroid therapy in a case of idiopathic interstitial pulmonary fibrosis (Hamman-Rich syndrome) showed no evidence of the changes seen in the initial biopsy specimen. This was in keeping with the improvement experienced by the patient and evidenced by the results of pulmonary-function tests and serial thoracic roentgenograms. Massive doses of corticosteroids may be useful in this disease if initial response to treatment is disappointing.

Author Affiliations
From the Cardiopulmonary Laboratory and Pulmonary Diagnostic Unit, US Air Force Hospital, Scott Air Force Base, Ill (Dr. Gracey), and the Section of Medicine, Mayo Clinic and Mayo Foundation (Dr. Divertie). Dr. Gracey is now with the Veterans Administration Research Hospital, Chicago.; The views expressed herein are those of the authors and do not necessarily reflect the views of the Air University, the US Air Force, or the Department of Defense.

Footnotes
Reprint requests to Section of Publications, Mayo Clinic, Rochester, Minn 55901.

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ABSTRACT