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Hypokalemic Rhabdomyolysis and Myoglobinuria Following Amphotericin B Therapy
LCDR David J. Drutz, MC;
J. H. Fan, MD;
T. Y. Tai, MD;
J. T. Cheng, MD;
W. C. Hsieh, MD
JAMA. 1970;211(5):824-826.
Abstract
Amphotericin B-induced hypokalemia progressed to profound muscle weakness, rhabdomyolysis, and myoglobinuria in a patient with cryptococcal meningitis. Incomplete renal tubular acidosis which was present during therapy may have predisposed the patient to renal potassium wasting.
Author Affiliations
USNR
From the Department of Clinical Investigation, US Naval Medical Research Unit 2, Taipei, Taiwan (LCDR Drutz), and the Department of Internal Medicine, National Taiwan University College of Medicine, Taipei (Drs. Fan, Tai, Cheng, and Hsieh). Dr. Drutz is now with the USPHS Hospital and the Cancer Research Institute, University of California Medical Center, San Francisco.
Footnotes
The opinions and assertions contained herein are those of the authors and are not to be construed as official, or reflecting the views of the Navy Department or the naval service at large.
Reprint requests to Publications Editor, US Naval Research Unit 2, APO San Francisco 96263.
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