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Chromosome Abnormality in Offspring of LSD UserD Trisomy With D/D Translocation
Lillian Y. Hsu, MD;
Lotte Strauss, MD;
Kurt Hirschhorn, MD
JAMA. 1970;211(6):987-990.
Abstract
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.
Author Affiliations
From the departments of pediatrics (Drs. Hsu and Hirschhorn) and pathology (Dr. Strauss), Mount Sinai School of Medicine, City University of New York, New York. Dr. Hirschhorn is a Career Scientist of the Health Research Council of the City of New York (contract 1-513).
Footnotes
Reprint requests to 100th Street and Fifth Avenue, New York 10029 (Dr. Hsu).
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