This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

II. A Longitudinal Study of IgA and Neutralizing Antibody Levels in Nasal Washings From Men Infected With Influenza Virus

Roger D. Rossen, MD; William T. Butler, MD; Robert H. Waldman, MD; Robert H. Alford, MD; Richard B. Hornick, MD; Yasushi Togo, MD; Julius A. Kasel, PhD

JAMA. 1970;211(7):1157-1161.

Abstract
Following influenza virus infection, virus-neutralizing antibody was detected earlier, rose to high titers sooner, and was demonstrable more frequently in nasal washings from men who had had relatively high concentrations of immunoglobulin A (IgA) in their nasal washings prior to the infection. Four men who had relatively low levels of nasal IgA before inoculation were the only ones who experienced typical febrile influenza. Virus-neutralizing antibody was detected relatively late and infrequently in the postinoculation nasal washings from these men. These findings suggest that the immunologic response to influenza virus at the mucous membrane surface may play a role in limiting infection, and thereby avert clinical illness.

Author Affiliations
From the departments of microbiology and medicine, Baylor College of Medicine and the Laboratories of Immunology Research, the Methodist Hospital and the Veterans Administration Hospital, Houston (Drs. Rossen and Butler); the departments of medicine and microbiology, University of Florida, College of Medicine, Gainesville (Dr. Waldman); the Department of Medicine, Vanderbilt University School of Medicine and Veterans Administration Hospital, Nashville, Tenn (Dr. Alford); the Division of Infectious Diseases, Department of Medicine, University of Maryland, Medical School, Baltimore (Dr. Togo); and the Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, Bethesda, Md (Dr. Kasel).

Footnotes
Reprint requests to Immunology Research Laboratory, Veterans Administration Hospital, Houston 77031 (Dr. Rossen).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Psychoneuroimmunology: The New Frontier
JEMMOTT
American Behavioral Scientist 1985;28:497-509.
 

Synthesis and Secretion of Secretory Immunoglobulins: With Special Reference to Dental Diseases
Brandtzaeg
JDR 1976;55:C102-C114.
 

Immunogenicity of Inactivated Influenza Virus Vaccine in Chronic Renal Failure
JORDAN et al.
ANN INTERN MED 1973;79:790-794.
ABSTRACT