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Comparison of Cardiac vs Noncardiac Irradiation

Franco M. Muggia, MD; Nemetallah A. Ghossein, MD; Albert Hanok, MS

JAMA. 1970;211(8):1345-1350.

Abstract
Twenty-one patients receiving irradiation to major portions of the heart and 24 patients receiving noncardiac irradiation had serial determinations of serum enzymes including lactic acid dehydrogenase (LDH), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and creatine phosphokinase (CPK) before, during, and after therapy. The following conclusions were reached: (1) the serum LDH and SGOT values are not useful to detect radiation-induced myocardial damage since they (as well as the SGPT) are frequently abnormal and likely to reflect a variety of complications related to the neoplastic disease itself; (2) the CPK remains normal in patients receiving irradiation to various tumors, including large areas of skeletal muscle and the right border of the heart, but excluding the major muscular portion of the heart; and (3) a rise in CPK value, noted in five patients during and in two patients following irradiation to the heart, may reflect radiationinduced myocardial damage.

Author Affiliations
From the departments of medicine, radiology, and biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY.

Footnotes
Reprint requests to 1825 Eastchester Rd, Bronx, NY 10461 (Dr. Ghossein).

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