 |
|
Myocardial Metabolism in Children Having Open-Heart Surgery
Emerson A. Moffitt, MD;
John W. Rosevear, MD;
Dwight C. McGoon, MD
JAMA. 1970;211(9):1518-1524.
Abstract
The electrolyte and metabolic responses to operation and whole-body perfusion for correction of congenital cardiac defects were studied in nine children. Whole-body metabolism was not different between cyanotic and noncyanotic patients, but in the cyanotic group the myocardium tolerated periods of aortic clamping with less anaerobic glycolysis as compared to considerable lactate production during perfusion and anoxic asystole in the noncyanotic group. More severe ketosis developed postoperatively in children than in adults. The increase in serum insulin from the glucose load of the priming solution was greater in children than in adults. Lipid was metabolized predominantly by the body for energy in spite of adequate glucose available, as seen in starvation and stress. Nonesterified fatty acids continued to be the major myocardial energy-producing substrate, although lactate, ketone bodies, and pyruvate were also extracted.
Author Affiliations
From the sections of anesthesiology (Dr. Moffitt), biochemistry (Dr. Rosevear), and surgery (Dr. McGoon), Mayo Clinic, and Mayo Foundation, Rochester, Minn.
Footnotes
Read before the Section on Anesthesiology at the 118th annual convention of the American Medical Association, New York, July 16, 1969.
Reprint requests to Mayo Clinic, Rochester, Minn 55901.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Retrograde Insufflation of Gaseous Oxygen Into the Coronary Sinus as a Means of Myocardial Maintenance
Brown et al.
Arch Surg 1972;105:622-627.
ABSTRACT
Recent Advances in Management of Functioning Islet Cell Tumor
Ferris et al.
Arch Surg 1972;104:443-446.
ABSTRACT
Circulating Glucose and Insulin in Surgery for Insulomas
Schnelle et al.
JAMA 1971;217:1072-1078.
ABSTRACT
|
