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M. L. Leu, MD; CDR G. Thomas Strickland, MC; C. C. Wang, MD; T. S. N. Chen, MD

JAMA. 1970;211(9):1542-1543.

Abstract
Twelve of 20 patients (60%) with Wilson's disease (hepatolenticular degeneration) were noted to have hyperpigmentation on the anterior aspect of the lower part of the legs. Histologically, this was found to be caused by increased melanin deposition. Copper and iron content in skin biopsy specimens was not different from that in controls.

Author Affiliations
USN

From the Clinical Investigation Department, US Naval Medical Research Unit No. 2, Taipei, Taiwan.

Footnotes
The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department or the Naval Service at large.

Reprint requests to Publications Office, NAMRU-2, Box 14, APO San Francisco 96263.

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