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David G. Logan, MD; Sharad D. Deodhar, MD, PhD

JAMA. 1970;212(10):1703-1704.

Abstract
Previous studies on the detection of circulating and tissue-fixed antibody to certain parts of the brain of schizophrenic patients had suggested that schizophrenia may be an autoimmune disease. We attempted a similar study of this antibody in the brain tissue of eight schizophrenic patients, nine (control) patients with organic brain diseases, and in three serum samples of acutely schizophrenic patients. No evidence of fixed or circulating antibody was found in any of these cases. These results make it difficult to sustain a role for autoimmunity in schizophrenia.

Author Affiliations
From the Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland (Dr. Logan), and the divisions of pathology and research, the Cleveland Clinic Foundation (Dr. Deodhar).

Footnotes
Reprint requests to 2020 E 93rd St, Cleveland 44106 (Dr. Deodhar).

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ABSTRACT