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Harold E. Booker, MD; Raymond W. M. Chun, MD; Miguel Sanguino, MD

JAMA. 1970;212(13):2262-2263.

Abstract
A myasthenic reaction in an 8-year-old girl developed within a few months during treatment of petit mal seizures with trimethadione. Progressive bulbar weakness culminated in a crisis with respiratory failure following a major convulsion. Initially, large doses of neostigmine (Prostigmin) methylsulfate were required, but a complete remission occurred within six months after trimethadione was withdrawn. This case is remarkably similar to the case described by Peterson,¹ and supports his hypothesis that an auto-immune response to trimethadione was the responsible mechanism.

Author Affiliations
From the Epilepsy Center, University of Wisconsin Medical Center, Madison.

Footnotes
Read before the American Academy of Neurology, Chicago, April 25, 1968.

Reprint requests to 1300 University Ave, Madison, Wis 53706 (Dr. Booker).

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