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Keith W. Ashcraft, MD; Lucian L. Leape, MD

JAMA. 1970;212(3):454-456.

Abstract
Five of 22 surgical patients being treated with parenteral nutrition developed Candida albicans septicemia. Two died of this infection. All of these patients demonstrated factors known to predispose to or promote Candida sepsis. Failure of weight gain in an infant, fever otherwise unexplained, or the known presence of Candida infection elsewhere should alert the physician to the possibility of Candida septicemia. Regular periodic blood cultures may reveal organisms in the mildly symptomatic patient and facilitate early diagnosis. Treatment is removal of the central venous catheter. Amphotericin B therapy may also be required in severe cases.

Author Affiliations
From the Section of Pediatric Surgery, Department of Surgery, University of Kansas School of Medicine and Medical Center, Kansas City, Kan.

Footnotes
Reprint requests to University of Kansas Medical Center, Rainbow Boulevard at 39th Street, Kansas City, Kan 66103 (Dr. Leape).

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