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Pulmonary Function and Cardiopulmonary Bypass
Jawahar Ghia, MD;
Nikaan B. Andersen, MD
JAMA. 1970;212(4):593-597.
Abstract
In adults and children, we measured airway resistance, compliance, alveolar-arterial oxygen gradient (100% oxygen), and dead space:tidal volume ratio early and late in anesthesia. Operations performed included cardiac bypass, and thoracic, abdominal, and surface procedures. Airway resistance increased when the pleura was opened. However, with intact pleurae even cardiopulmonary bypass had no effect on pulmonary performance. The deleterious effects of pleurotomy were alleviated by humidification of the inspired-gas mixture, and, during cardiopulmonary bypass, by providing intermittent deep breaths. We concluded that pleurotomy impairs pulmonary function primarily through retraction of the lungs and through retainment of secretions.
Author Affiliations
From the Department of Anesthesiology, University of Florida College of Medicine, Gainesville. Dr. Ghia is now with US Army Hospital, US Military Academy, West Point, NY. Dr. Andersen is now with Case-Western Reserve School of Medicine, and University Hospital, Cleveland.
Footnotes
Reprint requests to 2065 Adelbert Rd, Cleveland 44106 (Dr. Andersen).
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