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Some Biochemical Characteristics

Meyer Friedman, MD; Sanford O. Byers, PhD; Ray H. Roseman, MD; Franklin R. Elevitch, MD

JAMA. 1970;212(6):1030-1037.

Abstract
Studies of the plasma triglyceride, free fatty acids, cholesterol, glucose, uric acid, cortisol, insulin, growth hormone, and thyroxine values of relatively "coronary-prone" (behavior type A) and relatively coronary "resistant" (behavior type B) subjects were performed. The group of coronary-prone subjects not only exhibited abnormally high plasma triglyceride (both before and after fat feeding) and cholesterol values but also a hyperinsulinemic response to a glucose challenge. There was also suggestive evidence of a decreased content of growth hormone in the plasma of the same coronary-prone subjects. Plasma levels of free fatty acids, uric acid, glucose, cortisol, and thyroxine, however, were not elevated in these same subjects.

Author Affiliations
From the Harold Brunn Institute (Drs. Friedman, Byers, and Roseman) and the Department of Clinical Pathology (Dr. Elevitch), Mount Zion Hospital and Medical Center, San Francisco.

Footnotes
Reprint requests to 1600 Divisadero St, San Francisco (Dr. Friedman).

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