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Acral Changes Associated With Thyroid Diseases
Daniel W. Nixon, MD;
Ellis Samols, MD
JAMA. 1970;212(7):1175-1181.
Abstract
Acral changes associated with thyroid diseases include exophthalmos, local myxedema, and acropachy, which may conveniently be grouped together for pathological and clinical reasons. This communication discusses 16 patients with acral changes following antithyroid therapy, and 8 patients who had not been hyperthyroid or received any form of thyroid ablation. Local myxedema or bone changes of acropachy may not be recognized on clinical examination unless the clinical and roentgenological features are known. Original diagnostic criteria include decreased skin temperature over early local myxedema, and increased width of the diaphysis of distal short bones. Differential diagnoses include acromegaly, pachydermoperiostosis, neurotic arthralgias, and hypertrophic pulmonary osteoarthropathy. Local trauma may determine the site of acral changes.
Author Affiliations
From the Department of Medicine, Medical College of Georgia, Augusta.
Footnotes
Reprint requests to 1120 15th St, Augusta, Ga 30902 (Dr. Nixon).
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