This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Janet B. Hardy, MD; Paul H. Hardy, MD; Ella H. Oppenheimer, MD; Stephen J. Ryan, Jr., MD; Robert N. Sheff, MD

JAMA. 1970;212(8):1345-1349.

Abstract
A newborn had congenital syphilis, which was characterized by wide-spread infection of meninges, liver, pancreas, peritoneum, and long bones. In spite of treatment given to the mother ten days prior to delivery, and massive doses of penicillin G potassium given to the infant for 17 days after birth, viable and virulent Treponema pallidum were recovered from both the aqueous fluid and ground eye tissue removed at the autopsy, which was performed when the child died at age 22 days.

Author Affiliations
From the departments of pediatrics (Drs. J. Hardy and Sheff), obstetrics (Dr. J. Hardy), microbiology (Dr. P. Hardy), pathology (Dr. Oppenheimer), and ophthalmology (Dr. Ryan), the Johns Hopkins School of Medicine, and the International Treponematoses Laboratory of the World Health Organization (Dr. P. Hardy), Johns Hopkins University, Baltimore.

Footnotes
Reprint requests to Johns Hopkins Hospital, Baltimore 21205 (Dr. J. Hardy).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

UK National Guidelines on the Management of Syphilis 2008
Kingston et al.
Int J STD AIDS 2008;19:729-740.
FULL TEXT  

Molecular Evolution of the tprC, D, I, K, G, and J Genes in the Pathogenic Genus Treponema
Gray et al.
Mol Biol Evol 2006;23:2220-2233.
ABSTRACT | FULL TEXT  

Antibody Responses Elicited against the Treponema pallidum Repeat Proteins Differ during Infection with Different Isolates of Treponema pallidum subsp. pallidum
Leader et al.
Infect. Immun. 2003;71:6054-6057.
ABSTRACT | FULL TEXT  

Pituitary Gland Gumma in Congenital Syphilis After Failed Maternal Treatment: A Case Report
Benzick et al.
Pediatrics 1999;104:4e-4.
ABSTRACT | FULL TEXT  

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features
Singh and Romanowski
Clin. Microbiol. Rev. 1999;12:187-209.
ABSTRACT | FULL TEXT  

Maternal and Congenital Syphilis in Brooklyn, NY: Epidemiology, Transmission, and Diagnosis
Rawstron et al.
Arch Pediatr Adolesc Med 1993;147:727-731.
ABSTRACT  

Effect of Human Immunodeficiency Virus (HIV) Infection on the Course of Syphilis and on the Response to Treatment
Musher et al.
ANN INTERN MED 1990;113:872-881.
ABSTRACT  

Congenital Syphilis: Why Is It Still Occurring?
Mascola et al.
JAMA 1984;252:1719-1722.
ABSTRACT