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J. Worth Estes, MD

JAMA. 1970;212(9):1492-1495.

Abstract
The kinetics of heparin's anticoagulant activity were studied with four assay methods in human subjects, following single intravenous doses within the usual clinical dose range. The half-life of anticoagulant activity was about 1.5 hours. Minimum doses of heparin required to anticoagulate blood to a clinically desirable extent were about 35 units/kg. Of the four tests used, the whole-blood activated partial thromboplastin time provided the greatest precision, information, and economy, followed by, in order, the activated plasma partial thromboplastin time, the whole blood clotting time, and the partial thromboplastin time of plasma.

Author Affiliations
From the Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston.

Footnotes
Read in part before the American Society of Pharmacology and Experimental Therapeutics, Pittsburgh, August, 1969.

Reprint requests to 80 E Concord St, Boston 02118 (Dr. Estes).

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