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C. Norman Shealy, MD; John B. Weeth, MD; Dorothy Mercier

JAMA. 1970;212(9):1522-1523.

Abstract
Asymptomatic livedo reticularis has appeared in ten of 18 female patients with parkinsonism treated with amantadine hydrochloride. Although no serious effects have been seen to date, a livedo reticularis type manifestation has been associated at times with serious collagen disorders such as periarteritis nodosa and lupus erythematosus. Although amantadine has distinct beneficial effects in parkinsonism, long-term use should be viewed with some caution.

Author Affiliations
From the Gundersen Clinic, Ltd., La Crosse, Wis.

Footnotes
Reprint requests to 1836 South Ave, La Crosse, Wis 54601 (Dr. Shealey).

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