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Robert J. Fass, MD; Robert L. Perkins, MD; Samuel Saslow, MD, PhD

JAMA. 1970;213(1):121-123.

Abstract
Six (8%) of 75 patients treated with cephaloridine developed a positive direct Coombs' test (DCT). Five of the six were receiving the maximum dose used (4 gm/day) and all were older than the age of 47 years. Positivity was most related to duration of therapy and total dose of drug administered. It was unrelated to serum concentrations of cephaloridine or to hypoalbuminemia and occurred in patients with normal renal function. The incidence of Coombs' positivity with cephaloridine was lower than that previously reported with cephalothin sodium but was likewise unassociated with hemolysis.

Author Affiliations
From the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio.

Footnotes
Reprint requests to 410 W Tenth Ave, Columbus, Ohio 43210 (Dr. Fass).

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