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Succinylcholine-Induced Hyperkalemia in Neuromuscular Disease
Lee H. Cooperman, MD
JAMA. 1970;213(11):1867-1871.
Abstract
The dangerously high levels of plasma potassium known to follow succinylcholine chloride administration in patients with burns or trauma have also been noted in patients with paraplegia or hemiplegia, muscular dystrophy, and multiple sclerosis. Of 40 patients with these neuromuscular diseases, 15 had increases in potassium levels between 1 and 6 mEq/liter after receiving succinylcholine chloride, 1 mg/kg of body weight. Most increases over 1 mEq/liter occurred in those patients who had been ill for less than six months or, if longer, who had disease of a progressive nature. The degree and extent of muscle paralysis seemed directly correlated with relaxant-induced hyperkalemia.
Author Affiliations
From the Department of Anesthesia, University of Pennsylvania School of Medicine, Philadelphia.
Footnotes
Reprint requests to 3400 Spruce St, Philadelphia 19104 (Dr. Cooperman).
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