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Leah M. Lowenstein, MD, DPhil; Rosemary Simone; Phillip Boulter, MD; Peter Nathan, PhD

JAMA. 1970;213(11):1899-1901.

Abstract
Fructose has previously been found to be the most effective experimental compound in increasing the metabolism of alcohol (ethanol). In this clinical study, fructose, glucose, or saline infusions were administered intravenously to subjects who simultaneously drank 300 ml of bourbon. Fructose infusions resulted in a lowering of the alcohol levels in the blood by 43% compared to the values obtained during saline solution infusions. Glucose infusions were ineffective. The lowering of the alcohol levels by fructose may occur because the dissociation of the alcohol dehydrogenase-NADH complex is accelerated by intermediary metabolites of fructose.

Author Affiliations
From the Alcohol Study Unit, Boston City Hospital, Harvard Medical School, and Boston University Medical School.

Footnotes
Reprint requests to 15 Stoughton St, Boston 02118 (Dr. Lowenstein).

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