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Studies on the Detection of Adverse Drug Reactions in the NewbornI. Fetal Exposure to Maternal Medication
Werner A. Bleyer, MD;
William Y. W. Au, MD;
William A. Lange, Sr., MD;
Lawrence G. Raisz, MD
JAMA. 1970;213(12):2046-2048.
Abstract
The drugs taken by 67 consecutive private patients during the last trimester of pregnancy have been analyzed by means of a maternal diary composed of a day-by-day medication record. Each mother took an average of 8.7 drugs during the period of study (three to nine weeks), when the drugs contained in multiple drug combinations are included. An average of 6.9 (80%) of these were taken without medical supervision or knowledge, and 1.8 (20%) were specifically ordered by the doctor. Next to vitamins, the most commonly used drugs were aspirin (69% of patients) and antacids (60% of patients). By using a personal medication record, the intake of drugs including those not ordinarily considered as "medicines" can be assessed in an outpatient population.
Author Affiliations
From the departments of medicine (Drs. Au and Raisz), pharmacology (Drs. Bleyer, Au, and Raisz), and obstetrics and gynecology (Dr. Lange), University of Rochester (NY) School of Medicine and Dentistry; and the Rochester (NY) General Hospital. Dr. Bleyer is now with the University Hospital, University of Washington, Seattle.
Footnotes
Reprint requests to 260 Crittenden Blvd, Rochester, NY 14620 (Dr. Raisz).
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