 |
|
Studies on the Detection of Adverse Drug Reactions in the NewbornII. The Effects of Prenatal Aspirin on Newborn Hemostasis
Werner A. Bleyer, MD;
Robert T. Breckenridge, MD
JAMA. 1970;213(12):2049-2053.
Abstract
The effects of prenatal medications on newborn hemostasis were investigated in 43 infants by comparing accurate prenatal drug histories with clinical and laboratory studies done postpartum. Fourteen newborns exposed to aspirin during the week prior to birth were compared to 17 children whose mothers had not taken aspirin. Two potentially adverse drug reactions were detected. Platelet dysfunction (inhibition of collagen aggregation) and diminished factor XII (Hageman factor) activity were found in neonates born of mothers who had taken aspirin during the last week of pregnancy. In this group, bleeding was limited to one incident each of cephalhematoma, purpura, and transient melena. In the group not exposed to aspirin, hemorrhagic conjunctivitis developed in one infant on the second day of life. Until the clinical significance of these findings is more fully evaluated, it would seem prudent to restrict aspirin during the last month of gestation.
Author Affiliations
From the Department of Medicine, University of Rochester (NY) School of Medicine and Dentistry and the Rochester General Hospital. Dr. Bleyer is now with the University of Washington, Seattle.
Footnotes
Reprint requests to Rochester General Hospital, Rochester, NY (Dr. Breckenridge).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Severe Intracranial Hemorrhage in a Term Neonate Associated With Maternal Acetylsalicylic Acid Ingestion
Karlowicz and White
CLIN PEDIATR 1993;32:740-743.
Effects of Aspirin and Acetaminophen in Pregnancy and in the Newborn
Rudolph
Arch Intern Med 1981;141:358-363.
ABSTRACT
Editor's Commentary
CLIN PEDIATR 1974;13:345-346.
|
